Modification of trna, Biology

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Transfer RNA molecules are notable for having generally nucleotides shown in the figure such as 1-methylguanosine (m1G), pseudouridine   (Ψ), dihydrouridine   (D), inosine (I) and 4-thiouridine (S4U). These are formed through modification of guanosine and uridine after tRNA synthesis. For instance, inosine is produced by deamination of guanosine.

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                       Figure:  Some modified nucleosides found in tRNA molecules.

 


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