Mechanism of enzyme action, Biology

Mechanism  of Enzyme Action

 The action of enzymes is to lower  the activation energy  or threshold  of their substrates which. Therefore  become  activated and   react  with  the other reactants  .The  specific amino acid  sequence and molecular shape of the  enzyme  are of primary  importance in this function but its  mechanism is not yet properly under stood  ,The main  views  have been  expressed  t explain  this mechanism .

1. Lock and key or Template Hypothesis: Emil Fischer  1894  hypothesized  that each  enzyme molecule  has a specific and  rigid  active  site upon its surface .A reactant molecule having a matching  geometrical  configuration   only  can fit into this  active  site  of enzyme  like  a key fitting   into a lock forming an unstable enzyme substrate complex ,This  linkage actives the  substrate molecules  to react readily with  the other reactant of the  reaction

2. Induced fit Model Hypothesis: The  lock and key model has been  modified  by koshland 1971 and his co-workers  who  have suggested that the active silt  of an enzyme  molecule  is flexible. As  the specific  substrate molecule links with the  enzyme  molecule the latter undergoes conformation changes  so that the  fit  is improved the  reactive groups of enzyme  molecule move to their  proper sites.

Posted Date: 10/4/2012 2:07:51 AM | Location : United States







Related Discussions:- Mechanism of enzyme action, Assignment Help, Ask Question on Mechanism of enzyme action, Get Answer, Expert's Help, Mechanism of enzyme action Discussions

Write discussion on Mechanism of enzyme action
Your posts are moderated
Related Questions
How Parasitic infections are found? Parasitic infections are found throughout the world. With increasing travel, immigration, use of immunosuppressive drugs and the spread of A

NEUROPSYCHOLOGICAL BATTERY The battery was published in 1980 by Western Psychological Services and is now extensively used in clinical and research applications. An alternate

Explain Atrial Switch Operation ? The hospital mortality reported varies between 0 and 15 per cent. Late survival is worse for TGA with VSD compared to simple TGA. 15 year surv

How do you determine net atp production after complete oxidation to CO2 and H2O using mitochondrial?-oxidation, the TCA cycle, the mitochondrial electron transport chain and oxidat

Economic Significance - Conservation of Wildlife Certain wild species are important because of their actual or potential economic value to people. Wildlife resources provide p

Q. How many chambers does the fish heart have? The fish heart is a tube made of two consecutive chambers such as one ventricle and one atrium.


Define the Public Nutrition Public nutrition is concerned with improving nutrition in populations in both poor and industrialized countries, linking with continuity and public

Hypothalamus functions are generally aimed at maintaining A region in the brain beneath the thalamus; consists of number of aggregations of nerve cells and controls a variety of a

true or false. the law of entropy says that all energy is ultimately derived from the sun