Introduction to physiologically based pharmacokinetics in dr, Science

Although certain physiological aspects of disposition of substances by organs within the body had received atten-tion earlier, it was in 1937, with the seminal work of Teorell, that an integrated approach to whole body physiologically based modeling of pharmacokinetics received first serious attention. However, owing to the resultant mathematical and computational complexities and the lack of some basic physiological information at the time, whole body physiological based pharmacoki-netics (PBPK) did not become of age until the 1960s, when, with the aid of the digital computer, modeling contributions from the chemical engineering community reawakened interest in this area. Since then, there have been numerous applications of the approach to a wide variety of chemical and drug substances, varying from small to large molecules, as well as investigations with environmental compounds. Compared, for example, to the sum of exponentials modeling, which is purely de-scriptive of the observed behavior of the substance under investigation, whole body PBPK modeling provides a mechanistic and more realistic description of the behav-ior of the substance in various tissues, with the intent of addressing such questions as: Why do we see the ob-served behavior? Can we explain differences among compounds? Can we better predict pharmacokinetics in human from in vitro and preclinical information and provide increasingly confident predictions of events oc-curring with drugs at target and other sites (which are rarely directly observable in humans), with age, in dis-ease, and when co-administered with other drugs.

Cation by industry and in regulatory submissions. Yet, there is an increasing impetus for the use of PBPK mod-eling within industry driven in part by the desire to make more efficient and informed selection of compounds for development from the myriad coming out of combinato-rial chemistry and high throughput biological screens, and in part from the general increasing acceptance of modeling in drug discovery and development as wit-nessed, for example, in the widening use in clinical trial design and simulation. Moreover, an increasing body of physiological, biological, and pharmacological data has become available over the years to inform PBPK model-ing. Collectively, these factors created the impetus for, and suggested the timeliness of, the workshop.

Posted Date: 2/15/2013 4:21:38 AM | Location : United States







Related Discussions:- Introduction to physiologically based pharmacokinetics in dr, Assignment Help, Ask Question on Introduction to physiologically based pharmacokinetics in dr, Get Answer, Expert's Help, Introduction to physiologically based pharmacokinetics in dr Discussions

Write discussion on Introduction to physiologically based pharmacokinetics in dr
Your posts are moderated
Related Questions
Dating  the Past: Today, that  a particular  rock  is a million ycars old, or a fossil is 50 thousand ycars old. For  instance, how do we estimate the duration of various geo


Structure of Atoms Elements are pure substances. Elements are composed of a single kind of atom, as opposed to compounds which contain two or more kinds of atoms (see lesson 5).

Explain the Respiratory Adjustments Certain adjustments need to be made inside our body as well, to cope up with the varying environmental conditions, as well as, abnormal and

Soil Texture and Methods of Analysis Soil texture is the basic property of a soil  related to the  size of individual mineral particles, which cannot be easily altered.  It spe

difference between micro and macro nutrients

Digestion in the Mouth The mouth  receives food. The tongue serves  in  swallowing, manipulating the food for chewing and  in perceiving taste. The teeth mechanically subdivide

Explain Pus Formation Once a neutrophil finds a foreign particle or a bacterium, it will engulf it releasing enzymes, hydrogen peroxide and other chemicals from its granules to

What is First Aid? First-aid is the immediate and temporary care given to the victim of an accident or sudden illness. Its purpose is to (1) help preserve life, (2) preve

The digestive system is made up of two groups of organs: Alimentary  tract, which  includes mouth, pharynx,  oesophagys,  stomach, small intestine,  large intestine, appendix