Introduction to physiologically based pharmacokinetics in dr, Science

Although certain physiological aspects of disposition of substances by organs within the body had received atten-tion earlier, it was in 1937, with the seminal work of Teorell, that an integrated approach to whole body physiologically based modeling of pharmacokinetics received first serious attention. However, owing to the resultant mathematical and computational complexities and the lack of some basic physiological information at the time, whole body physiological based pharmacoki-netics (PBPK) did not become of age until the 1960s, when, with the aid of the digital computer, modeling contributions from the chemical engineering community reawakened interest in this area. Since then, there have been numerous applications of the approach to a wide variety of chemical and drug substances, varying from small to large molecules, as well as investigations with environmental compounds. Compared, for example, to the sum of exponentials modeling, which is purely de-scriptive of the observed behavior of the substance under investigation, whole body PBPK modeling provides a mechanistic and more realistic description of the behav-ior of the substance in various tissues, with the intent of addressing such questions as: Why do we see the ob-served behavior? Can we explain differences among compounds? Can we better predict pharmacokinetics in human from in vitro and preclinical information and provide increasingly confident predictions of events oc-curring with drugs at target and other sites (which are rarely directly observable in humans), with age, in dis-ease, and when co-administered with other drugs.

Cation by industry and in regulatory submissions. Yet, there is an increasing impetus for the use of PBPK mod-eling within industry driven in part by the desire to make more efficient and informed selection of compounds for development from the myriad coming out of combinato-rial chemistry and high throughput biological screens, and in part from the general increasing acceptance of modeling in drug discovery and development as wit-nessed, for example, in the widening use in clinical trial design and simulation. Moreover, an increasing body of physiological, biological, and pharmacological data has become available over the years to inform PBPK model-ing. Collectively, these factors created the impetus for, and suggested the timeliness of, the workshop.

Posted Date: 2/15/2013 4:21:38 AM | Location : United States

Related Discussions:- Introduction to physiologically based pharmacokinetics in dr, Assignment Help, Ask Question on Introduction to physiologically based pharmacokinetics in dr, Get Answer, Expert's Help, Introduction to physiologically based pharmacokinetics in dr Discussions

Write discussion on Introduction to physiologically based pharmacokinetics in dr
Your posts are moderated
Related Questions
Let us recall briefly what all we have learnt about fire hazards in this unit. Fire accident can happen due .to a number of reasons, like, flammable liquids, faulty electrical and

Interaction in the earth ecosystem: In this comparatively smaller section, we will give you  the idea, that the earth as a whole is an ecosystem. Whatever you  have learnt till

What are the Factors Affecting Soil Formation  Parent materials formed due to weathering of rocks are transported from the place of their origin and re-deposited before they ar

Explain how Insulin Secretion Regulated It is interesting to note that blood sugar level itself controls insulin secretion. How? When blood sugar level rises, insulin secretion

What is the function of the connective tissue?

what is the photosynthesis?

Explain Saliva - External Defence Mechanism Saliva contains microorganisms which are not the normal inhabitants. Dead microbes are passively flushed by the saliva and are swall

Types of Diseases As we  have indicated above. there are diseases,that  a person is born with, for example, a baby may have a defective heart at the time of its birth. Then t

Explain the Transfusion of Blood Blood has been considered as the elixir of life. However, in ancient times, patients were bled to get rid of their foul fluid. Later, as blood

To show that soil contains air:- Place some soil in a glass jar or bottle and slowly pour water over it. Observe the air bubbles that increase by the water from the soil.