Hirschsprungs disease, Biology

Hirschsprungs Disease (Congenital Megacolon):

This  is also known as congenital megacolon. There is absence of ganglion cells, submucus plexus  and intramural plexus  (parasympathetic ganglion cells)  in distal segment usually rectosegmoid  junction. Incidence  is one in 5000  live birth.  

It is more common in males  than in females. 

In Hirschsprungs Diseasefthere is an arrest in embroylogic development affecting the migratioon  of parasympathetic nerves (innervation) of  the intestine occuring before 12 weeks of gestation due to genetic cause. This leads to the functional obstruction of the colon due  to  lack of peristalsis  in this area  leading  to  the accumulation of feces and gas proximal to the area of defected part. Due to accumulation of feces the colon becomes distended  so  the condition  is called as megacolon.

Nursing Assessment:

Neonate will present with failure to pass meconium and abdominal distention within a day or two after birth and if  rectal examination is done by  little finger there will be an explosive leakages of accumulated meconium and gas. There may be weight loss and dehydration due to bile-stained vomiting as a result of obstruction and failure to take fluid. Neonate may develop shock. Older childern will present with obstinate constipation with abdominal distention undernutrition and anorexia. There may be diarrhoea alternating with constipation due to bacterial action which liquefies the stool. The fecal mass can be palpated in left lower portion of  abdomen and rectal examination shows empty rectum. Diagnosis is supported by barium enema which shows constricted portion of aganglionic bowel distal to the dilated part of colon and diagnosis is confirmed by rectal biopsy which shows absent ganglion cells in submucosa and intermusular plexus with or without increased number of  nerve fibres.     

Posted Date: 10/26/2012 7:46:21 AM | Location : United States

Related Discussions:- Hirschsprungs disease, Assignment Help, Ask Question on Hirschsprungs disease, Get Answer, Expert's Help, Hirschsprungs disease Discussions

Write discussion on Hirschsprungs disease
Your posts are moderated
Related Questions
Is memory loss an early sign of Alzheimer's disease? A. Memory loss is one of the earliest symptoms of Alzheimer's disease and other kinds of dementia however occasional forget

Proteins of Animal Origin - Fish Fish: The edible portion is skeletal muscles of the body. Even though the skeletal muscles of different animals are basically similar, fish spe

what is the Symptoms of VIBRIO PARAHAEMOLYTICUS Symptoms: A total of greater than one million organisms may cause disease.  Symptoms of intoxication which range from mild to se

Biology is becoming a more quantitative science, a trend that has motivated and been recently spurred by advances in computing power and data-gathering technologies. Nowhere is th

Test of Deep vein Thrombophlebitis Place blood pressure cuff on unaffected calf and inflate until pain is elicited (usually greater than 150 mm Hg).  Place blood press

What are the kinds of plant geotropisms? Why do the root and the stem present opposite geotropisms? The kinds of geotropisms are the positive geotropism, that in which the plan

Toxoplasma cycles between its rodent and feline hosts, living out different phases of its existence in each. What is the scientific means about the cat and mouse?

Q. Explain diffrent type of Mycotoxins? Mycotoxins are secondary metabolites produced by molds on foodstuffs that cause illness or death when ingested by man or animals. The pr

Q. Goals of Dietary Treatment for dyslipidemia? The goals of dietary management (alone or conjunction with exercise or with lipid lowering drugs) are to reduce the total fat, s

Q. Management of Symptomatic Patients All symptomatic patients with severe aortic stenosis or even moderately severe aortic stenosis should undergo aortic valve replacement an