Factors affects oxygen dissociation curve -organic phosphate, Biology

Factors affects Oxygen Dissociation Curve -Organic Phosphate

The presence of organic phosphates in the red blood cells helps to explain many peculiarities of the oxygen dissociation curve. Previously the red blood corpuscle was considered to be a bag full of haemoglobin with no metabolism of its own because of the absence of a nucleus. Now we know that it has an active carbohydrate metabolism and RBC has high content of ATP and 2,3-diphosphoglycerate (DPG). 2, 3-DPG is a product of glycolysis and it binds to P chain of the globin and reduces oxygen affinity.

Experimentally it was shown that pure haemoglobin has greater oxygen affinity than whole blood (the dissociation curve for pure haemoglobin is far to the left of the curve for whole blood). If 2, 3-DPG is added to pure haemoglobin solution the oxygen affinity decreases and approaches that of whole blood. The effect of 2,3-DPG is also important in transfer of oxygen from maternal to foetal blood. Foetal haemoglobin is different from adult haemoglobin in having 2 6 chains instead of P chains. Foeta haemoglobin therefore cannot bind to 2, 3-DPG and thus has higher affinity for oxygen at a given Po2. This higher oxygen affinity in foetal blood facilitates oxygen transfer from mother to foetus.

Posted Date: 1/15/2013 8:09:33 AM | Location : United States







Related Discussions:- Factors affects oxygen dissociation curve -organic phosphate, Assignment Help, Ask Question on Factors affects oxygen dissociation curve -organic phosphate, Get Answer, Expert's Help, Factors affects oxygen dissociation curve -organic phosphate Discussions

Write discussion on Factors affects oxygen dissociation curve -organic phosphate
Your posts are moderated
Related Questions
Restriction of physical activities to reduce myocardial work and oxygen consumption. However, care should be taken to prevent deep vein thrombosis. - Oxygen administration in dy

What name is given to the population of genetically identical offspring which result from a process of asexual (vegetative) reproduction?   The population of genetically id

Cracking is the process in which large molecules are broken into smaller molecules.                      C 10 H 22         C 5 H 12 + C 5 H 10                      C 8 H

Q. What is the chemical equation of the aerobic cellular respiration? The chemical equation of the aerobic cellular respiration is given below: C 6 H 12 O 6 + 6 O 2 + 36 A

Cereal and Gram By-Products Agro-processing is now regarded as the sun rise sector in view of its large potential in maintaining the nutritional quality of processed feed resource

Which of the below refers to science concerned with the application of genetic principles to improvement of the human species? a) Eugenics b) Assortive mating c) Holandri

Explain about the physiology of eyelid movements. Physiology of Eyelid Movements: It is quoted that the eyelids move more than any other part of the body. The major movem

Types of Osmotic Exchanges The osmotic exchanges that take place between an animal and its environment are of two different types: Obligatory exchanges and Regulated

State the definition of soil The definition of soil has changed a great deal from a thin "outer layer of  Earth's crust" to "a collection of natural bodies on the surface of th

Thus, the objectives of the nutritional care process should include the following points: 1. Restoration of good nutritional status with dietary modifications and counseling.