Factors affects oxygen dissociation curve -organic phosphate, Biology

Factors affects Oxygen Dissociation Curve -Organic Phosphate

The presence of organic phosphates in the red blood cells helps to explain many peculiarities of the oxygen dissociation curve. Previously the red blood corpuscle was considered to be a bag full of haemoglobin with no metabolism of its own because of the absence of a nucleus. Now we know that it has an active carbohydrate metabolism and RBC has high content of ATP and 2,3-diphosphoglycerate (DPG). 2, 3-DPG is a product of glycolysis and it binds to P chain of the globin and reduces oxygen affinity.

Experimentally it was shown that pure haemoglobin has greater oxygen affinity than whole blood (the dissociation curve for pure haemoglobin is far to the left of the curve for whole blood). If 2, 3-DPG is added to pure haemoglobin solution the oxygen affinity decreases and approaches that of whole blood. The effect of 2,3-DPG is also important in transfer of oxygen from maternal to foetal blood. Foetal haemoglobin is different from adult haemoglobin in having 2 6 chains instead of P chains. Foeta haemoglobin therefore cannot bind to 2, 3-DPG and thus has higher affinity for oxygen at a given Po2. This higher oxygen affinity in foetal blood facilitates oxygen transfer from mother to foetus.

Posted Date: 1/15/2013 8:09:33 AM | Location : United States







Related Discussions:- Factors affects oxygen dissociation curve -organic phosphate, Assignment Help, Ask Question on Factors affects oxygen dissociation curve -organic phosphate, Get Answer, Expert's Help, Factors affects oxygen dissociation curve -organic phosphate Discussions

Write discussion on Factors affects oxygen dissociation curve -organic phosphate
Your posts are moderated
Related Questions
What event marks the beginning of the menstrual cycle? What is the blood concentration of FSH, LH, estrogen and progesterone in this phase of the cycle? By convention the menst


the appendages of arthropods; a. may serve as walking legs, b. may be modified into atennae, c. may be modified into large pincers, or d. all of the above

Energy from water or hydropower            Hydroelectricity is the energy produce from the kinetic energy of water falling from height. Approximately 25% of world electricity

Explain about the Glycemia or Insulinemia? Preliminary research evidence indicates that there may be beneficial effects in terms of decreased fasting blood glucose/hepatic gluc

Dissolved Gases and Alkalinity Dissolved Gases The marine environment serves as a gigantic reservoir of dissolved oxygen and carbon dioxide, which respectively help reg

Define the Role of Vitamin D in the immune system? Immune responses that are, mediated by T-cells can be inhibited by tile large doses of calcitriol i.e. 1, 25 dihydroxycholec

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

List the causes of implant failure due to improper surgical technique and placement. Failure due to surgical techniques and improper placement: a) Off axis / severe angulati

Which are the phases of the menstrual cycle? The menstrual cycle is separated into two main phases: the follicular (or menstrual) phase and the luteal (or secretory) phase.