Extracellular aging, Biology

Extracellular Aging

The basic components of extracellular space are mucopolysaccharides and fibrous proteins, particularly collagen and elastin. These proteins are synthesised in connective tissue and secreted out of the tissue. Collagen is predictable to form up to 40% of the body protein and fills the extracellular spaces. It has been recommended as the primary site of age related changes. Remember that collagen molecules are polymers of tropocollagen monomers. Newly polymerised molecules of collagen comprise non-covalent bonds and with age covalent cross-linking takes place between the monomers. Like the age of the organism increases cross-linking becomes much more hard to dissociate and by the time of maturity in mammals collagen becomes insoluble. From maturity to old age; cross-linking is strengthened and its effect can be computed. The age related changes in collagen are indisputable. Age related changes in the structure of collagen influence the functioning and structure of bones, tendon, blood vessels, joints, ligament etc. The inflexibility of collagen fibrils may be a contributory factor for the onset of atherosclerosis and hypertension.

Posted Date: 1/31/2013 7:05:15 AM | Location : United States







Related Discussions:- Extracellular aging, Assignment Help, Ask Question on Extracellular aging, Get Answer, Expert's Help, Extracellular aging Discussions

Write discussion on Extracellular aging
Your posts are moderated
Related Questions
Synapse   Nervous System Structural feature of unique importance in the nervous tissue is the synapse. A synapse is the anatomical site at which axon terminal processes of one

Animal Diseases - Diseases are common in domestic animals. Common signs of illness in animals are - 1.      Cessation of rumination. 2.      Drop in milk yield. 3.

Members belonging to the scientific community fear the misuse of this therapy leading to dangerous consequences.  People may try to insert the desired gene, for example, the gene f

#quesWhat benefits can commensalism offer to a species..

What are ganglia? Ganglia (singular ganglion), or neural ganglia, are structures located outside the central nervous system (for instance, beside the spinal column or near visc

Who did EPA consult with outside of the Agency in making this rule? EPA consulted with many agencies, organizations, and individuals in the process of finalizing the plant- inc

Why are the tropical forests also known as stratified forests? In tropical forests tall trees of various species have their crowns forming a superior layer under which diverse

In the sarcomere of a skeletal muscle, there are A. myosin molecules in the I band. B. both tropomyosin and myosin molecules in the region of the A band that is not in the H

Phylum Sporozoa 1) Thcy do not liavc any external locomotory dcvice and move by wriggling. 2) Reproduction by producing numerous spores. 3) All are parasites of animals,

What are enzyme cofactors? Some enzymes require other associated molecules to work. These molecules are known as enzyme cofactors and they can be, for example, organic ions lik