Explain the metabolic alterations during cancer, Biology

Explain the Metabolic Alterations during Cancer?

As we have studied earlier, patients with advanced cancer experience profound anorexia, early satiety, changes in the structure/function of organs/glands/body parts, several nutritional deficiencies and weight loss. Although the cause for these symptoms is not clear but they have definitely been found to be associated with the metabolic status of the patient. There are alterations in the energy expenditure, carbohydrate, protein and fat metabolism, acid -base balance, enzyme activities, and endocrine functions. Generally, there is an increased metabolic rate. For example, it may be 10 percent greater than the normal level. But, there are variations among patients with gastrointestinal cancers. Some patients may be hyper metabolic, whereas patients with colon and rectal cancer do not show any difference. Therefore, it is evident that there can be variations among patients. Let us now discuss these metabolic changes in detail.

Cancer patients have been shown to have glucose intolerance. This is due to an increased insulin resistance and also reduced insulin secretion. There are also many reports to show that there is an increased rate of endogenous glucose production ill cancer patients. This increased production combined with other carbohydrate changes is associated with weight loss. An increased rate of Cori cycling has been reported to occur in cancer patients.

Posted Date: 6/18/2013 6:43:49 AM | Location : United States

Related Discussions:- Explain the metabolic alterations during cancer, Assignment Help, Ask Question on Explain the metabolic alterations during cancer, Get Answer, Expert's Help, Explain the metabolic alterations during cancer Discussions

Write discussion on Explain the metabolic alterations during cancer
Your posts are moderated
Related Questions
What is Anatomic concavities Anatomic concavities present in the lingual surface of the mandible, the sublingual fossa anteriorly and the submandibular fossa posteriorly. Norm

Tracheal system in cockroach Cockroach belongs to phylum Arthropoda under invertebrate. They have specially developed tracheal system for respiration The system consis

Explain the Gall bladder disease - Effect of Obesity? Obesity is one of the risk factors for formation of gallstones. The super saturation of bile with cholesterol in obese ind

Sutures are also classified by thread diameter: Thread materials range in diameter from 1 to 10 with the higher number corresponding to the thinner, more delicate thread. In

Influence of Yolk on Cleavage Though biological significance of yolk is to provide nourishment to the developing embryo, it is not part of the active cytoplasm. Yolk is dead

Do all genetic diseases result from alteration in the number of chromosomes of the cells? Besides aneuploidies there are other genetic diseases, other chromosomal abnormalities

what is a protein-to-protein interaction in other words what 2 proteins must be together for transcription to take place and what 2 proteins for replication?

Open Head Injuries Open head injuries are TBIs in which the skull is penetrated, as in gun shot or missile wounds, or in which fragment of bone penetrate the brain substance. O

1. (a) Which physicochemical properties need to be regulated by the cell? Define chemical equilibrium and discuss how it is maintained by the cell. (b) Differentiate between facili