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Explain the Distant Osteogenesis
In this an extracellular matrix establishes the implant surface contact. The osteogenic cells line the host bone surface. The blood supply to these cells is between the cells and the implant and bone is laid down on the host bone surface. The implant surface will always be partially obscured from bone by intervening cells and the general connective tissue extracellular matrix. This type of healing has also been described to explain the phenomenon of "Osseointegration" of machined metallic implants. In distance osteogenesis, new bone is formed on the surfaces of old bone in the peri-implant site. The bone surfaces provide a population of osteogenic cells that lay down a new matrix which encroaches on the implant. In this, new bone is not forming on the implant, but the latter does become surrounded by bone and the implant surface will always be partially obscured from bone by intervening cells.
Rule of Distal Transformation of Blastema An intriguing phenomenon characteristic of limb regeneration is, that just only the part of the limb removed distal to the level of a
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