Explain the absorption of itraconazole capsules, Biology

Explain The absorption of itraconazole capsules

It is decreased with concurrent use of drugs that reduce gastric acidity, such as antacids, H2-receptor blockers, proton pump inhibitors or didanosine (Videx).

Itraconazole is a potent inhibitor of the hepatic isozyme CYP3A4 and may enhances serum concentrations of drugs that are metabolized by this enzyme. For this reason, itraconazole is contraindicated with the following drugs: cisapride  (Propulsid), dofetilide  (Tikosyn), ergot alka- loids, levomethadyl  (Orlaam),  lovastatin, oral midazolam (Versed, and others), pimozide  (Orap), quinidine, simvastatin, and triazolam (Halcion, and others). Itraconazole is itself also a substrate of CYP3A4; its metabolism may be affected by both inducers of the enzyme, such as rifampin and carbamazepine (Tegretol, and others), and by other inhibitors.

 

Posted Date: 6/26/2013 6:27:03 AM | Location : United States







Related Discussions:- Explain the absorption of itraconazole capsules, Assignment Help, Ask Question on Explain the absorption of itraconazole capsules, Get Answer, Expert's Help, Explain the absorption of itraconazole capsules Discussions

Write discussion on Explain the absorption of itraconazole capsules
Your posts are moderated
Related Questions
Q. Plant classification according to Ancient Greeks and Romans? Hippocrates, "The Father of Medicine" (460-377 B.C.) is reputed to have been one of Democritus 's disciples. He

CALCIUM It is the most abundant mineral of animal body. Calcium is available in all types of vegetables, grain, milk, cheese, eggs, fish and butter. By its deficiency r

Explain the Air Sampling? Microorganisms may be present in air of processing facility and have an impact on the quality and safety of foods processed and handled there. To avoi

Q. What is vision? Why is vision important for life on earth? Vision is the ability of some living beings to distinguish, to perceive and to interpret luminous stimuli. Visi

What is Risk scoring ? Risk scoring is an instrument to assess both the relative risk as well as the absolute risk of developing Cardio-vascular disease and mortality in an ind

Define Changes associated with the skeletal system - Ageing? Skeletal bone loss occurs with ageing and may have serious consequences among the elderly. With ageing, there is so

Adaptive radiation: The growth of a variety of species from the single ancestral form; occurs when a new habitat becomes accessible to a population. The evolutionary pattern of di

Determine the significance of Mesoglea. The jellylike layer found between endodermal and ectodermal cell layers of diploblastic organisms. It acts as a type of cement holding t

Q. Enumerate different implant materials? Biomaterials fall into four categories: metal and metal alloys, ceramics (carbon included in this group) synthetic polymers, and natur

Define Food Intake and Energy Requirements for Humans? Many studies have shown that the subjects loose significant amounts of body mass; fat mass, as well as, fat free mass du