Explain the absorption of itraconazole capsules, Biology

Explain The absorption of itraconazole capsules

It is decreased with concurrent use of drugs that reduce gastric acidity, such as antacids, H2-receptor blockers, proton pump inhibitors or didanosine (Videx).

Itraconazole is a potent inhibitor of the hepatic isozyme CYP3A4 and may enhances serum concentrations of drugs that are metabolized by this enzyme. For this reason, itraconazole is contraindicated with the following drugs: cisapride  (Propulsid), dofetilide  (Tikosyn), ergot alka- loids, levomethadyl  (Orlaam),  lovastatin, oral midazolam (Versed, and others), pimozide  (Orap), quinidine, simvastatin, and triazolam (Halcion, and others). Itraconazole is itself also a substrate of CYP3A4; its metabolism may be affected by both inducers of the enzyme, such as rifampin and carbamazepine (Tegretol, and others), and by other inhibitors.

 

Posted Date: 6/26/2013 6:27:03 AM | Location : United States







Related Discussions:- Explain the absorption of itraconazole capsules, Assignment Help, Ask Question on Explain the absorption of itraconazole capsules, Get Answer, Expert's Help, Explain the absorption of itraconazole capsules Discussions

Write discussion on Explain the absorption of itraconazole capsules
Your posts are moderated
Related Questions
Evolution can be explained as follows  1) The change in the life over time by adaptation, over-reproduction, variation and differential survival/reproduction, a procedure refer

Explain the Polycarbonate Nucleopore Filtre? A given sample is filtered through a membrane filter, usually polycarbonate nucleopore filter with a pore size that will retain bac

Following fertilization by a normal sperm, what chromosome condition is created?

Q. How do kidneys participate in the blood volume control? How is the blood volume of the body related to the arterial pressure? The kidneys and the hormones that act upon them

Iron deficiency Iron plays an essential role in oxygen transport in the body as a constituent of haemoglobin where nearly 60% of the body iron is found. Apart from oxygen tran

Explain An Overview of Water Soluble Vitamins? Vitamins, we already know, are classified by the materials in which they will dissolve. Fat-soluble vitamins -vitamin A, D, E a

Headache Associated with Neurological Diseases Headache is a symptom of many nervous system disorders, usually resulting from the distortion of pain sensitive structures. Commo

How body fat can be measured? The conventional golden method of measuring BF% is by underwater weighing. Difference of weight in air and in water gives density, from which the

Define the Fats requirement to avoid underweight problem?   We know that fats are concentrated source of energy (1g = 9 Kcals). Fats are capable of increasing the energy val

Q. What are the uses of National parks ? National Park is an area dedicated to conserve environment, natural and historical objects and to conserve the wild life therein. Natio