Explain knox''s test, Advanced Statistics

Knox's tests: These tests designed to detect any tendency for the patients with a particular disease to form the disease cluster in time and space. The tests are relied on a two-by-two contingency table formed from considering every pair of patients and classifying them as to whether members of the pair were or were not closer than the critical distance apart in space and as to whether the times at which they constricted the disease were closer than the opted critical period.

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