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Explain Adverse Effects of ganciclovir
Ganciclovir is teratogenic, carcinogenic and mutagenic and causes aspermatogenesis in animals. Granulocytopenia and thrombocytopenia, which are usually reversible, are more common with the IV formulation. Severe myelosuppression may occur more frequently when the drug is given concurrently with zidovudine. Granulocyte-colony-stimulating factors (GM-CSF; G-CSF) have been used to treat ganciclovir-induced neutropenia.
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