Epizootic lymphangitis, Biology

Epizootic lymphangitis


Epizootic lymphangitis (pseudo-glanders) is a chronic, insidious and highly contagious fungal disease of equines particularly horse and very rarely of cattle and man. It is caused by Histoplasma farcimininosum. Clinically, the disease is manifested by suppurative lymphangitis, lymphadenitis, ulcers of the skin, pneumonia, conjunctivitis and keratitis. The disease is of great economic importance as the sick animals cannot be utilized for the work. The incubation period is about 90 days and mortality rate goes up to 10-15%. Infection is transmitted directly by contact from the diseased to healthy animal or indirectly through contaminated material such as blanket, harness, grooming kit, bedding and other stable equipments. The fungus penetrates the body through subcutaneous abrasions and produces lesions at the site of entry. Experimentally, the disease can be transmitted to susceptible animals by subcutaneous or intradermal infection of pus from the lesion of diseased subject. Although stable- flies have also been reported as agents in the spread of the infection, their role as a vector in the transmission of the disease is not yet fully established.


Symptoms:
The primary lesion occurs in the subcutaneous tissues and later, infection spreads by the lymphatic vessels become enlarged, thickened, and corded; and later show nodules or hard abscesses, which rupture leaving indolent ulcer. Thick, creamy, bloodstained pus is noticed from these ulcers. The affected animals show general swelling of the limb particularly hock joint. Sometimes the infection may occur in nasal mucosa which later extends to pharynx, larynx and trachea. As a result the animal shows signs of sinusitis and primary pneumonia. Bone lesion is seldom seen in epizootic lymphangitis. Ocular form of disease is more common in mules than in other species of animals. The affected animal exhibits watery discharge from one or both the eyes, swelling of the eyelids, conjunctivitis, keratitis besides button-like ulcer on the membrana nictitans. The eye becomes closed due to diffuse swelling of the eyelids.


Diagnosis: Isolation of H. farciminosum on Brain Heart Infusion medium or Sabouraud‘s agar from the infected material confirms the diagnosis. However, the demonstration of gram-positive, oval, globose, pear-shaped, yeast-like cells (2.5-3.5
µm × 22.0 - 3.0 µm) with double - walled capsule in the pus smear may help in early diagnosis. Complement - fixation test and cantaneous test are useful aids in correct diagnosis. The disease is usually confused with ulcerative lymphangitis and cutancous sporotrichosis. In the former case, pus is greenish and lesions occur about fetlock which heal quickly. In sporotrichosis the pus smear reveals cigar-shaped bodies characteristic of the disease.


Treatment and prevention: In the early stage of the disease the affected part may be surgically removed under aseptic condition, and the wound may be dressed with silver nitrate or tincture or iodine or lactic acid or iodoform. Mercuric chloride in the  dosage of 30-50 ml (1: 1,000) may be tried intravenously. Daily intravenous injection of formal (5 ml diluted in 25 ml distilled water) for 15-21 days has also shown good result. The advanced cases should be destroyed, and all excreta and discharges properly disposed off. Besides, the bedding, harness, utensils and equipments should be thoroughly disinfected.

Posted Date: 9/17/2012 8:15:40 AM | Location : United States







Related Discussions:- Epizootic lymphangitis, Assignment Help, Ask Question on Epizootic lymphangitis, Get Answer, Expert's Help, Epizootic lymphangitis Discussions

Write discussion on Epizootic lymphangitis
Your posts are moderated
Related Questions
name a disorder of human blood that is caused by mutation

Which of the following best describes the reasons why the sliding clamp is able to confer processivity on DNA polymerase and not DNA primase? A. The sliding clamp coats the tem

Which of the following are bound to hemoglobin when hemoglobin is in the R-state? Choose all that apply. 1. Fe2+ 2. CO2 3. 2,3-bisphosphoglycerate 4. Fe3+ 5. Oxygen

Oxides of sulphur:          It includes SO 2 , SO 3 . It is a colorless gas having sharp, pungent and suffocating odour. It is soluble in water and forms H 2 SO 4 . Sourc

Endocytosis and Exocytosis Endocytosis is the process by which substances are brought into the cell from outside by formation of membrane bound vesicles. These extra cellular sub

MIDDLE LAMELLA It is thin, amorphous, intercellular matrix between 2 adjacent plant cell. The cells of plant tissue generally cemented together by an intercellular matrix

Other Complications of Prosthetic Valves :  One of the dreaded complications of mitral valve replacement is ventricular rupture. It is difficult to manage and so it is better avoi

Explain the Chemical Methods for Control of Microorganisms? Different chemicals can be used which can act as disinfectant, antiseptics or even chemical sterilants. These are:

Properties of Isozymes Isozymes differ from  each other not only in  the amino acid composition, they also have different electrophoretic property, thermolability, immunologi

what are the methods of seed formation