Describe the regulation of pyruvate dehydrogenase, Biology

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Describe the regulation of pyruvate dehydrogenase through covalent modification.

PDH exists in 2 forms :  Inactive, phosphorylated and Active, dephosphorylated. The active form of PDH is phosphorylated by a protein kinase with the help of ATP and Mg++ to  the inactive  form of PDH. Acetyl CoA  and NADH are activators for this action and CoA, NAD+,  and pyruvate are inhibitors. The inactive  form of PDH is dephosphorylated by phosphoprotein phosphatase to the active form in the presence of increased Ca++  ion concentration.

 


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