Describe lipoprotein, Biology

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.

Posted Date: 5/10/2013 5:17:37 AM | Location : United States







Related Discussions:- Describe lipoprotein, Assignment Help, Ask Question on Describe lipoprotein, Get Answer, Expert's Help, Describe lipoprotein Discussions

Write discussion on Describe lipoprotein
Your posts are moderated
Related Questions
Bronchiectasis: Bronchiectasis literally means abnormal dilation of bronchi. It is a chronic  inflammatory condition which is characterised  by permanent dilation of bronchi a

Define Energy and Protein requirements in geriatric nutrition? Decreased physical activity and changes in body composition and decreased basal metabolic rate affects the ma


Explain the Food Security? You were introduced to the concept of food security in Unit 2. Food security, we learnt, is access by all people at all times to enough food for an a

Dopamine is important for working memory and drug that increases the level of dopamine in the brain or facilities the action of dopamine, enhances working memory capabilities.Dopam

explain anatomy of bacteria

Explain about thiol proteases Group of  thiol proteases, similar in structure to each other, are found in plants. These include  papain from the papaya fruit and  ficain from f

What is Cerebral Hemorrhage Cerebral hemorrhage is a massive bleeding into the substance of the brain. The most frequent cause is high blood pressure, or hypertension. Other ca

Dracunculiasis (guineaworm infestation) Dracunculiasis, a disease of man, which has been known since antiquity, is caused by the nematode parasite Dracunculus medinesis. The p

Preference Share Capital or Quasi-Equity It is also called quasi-equity because it combines features of equity and those of debt.  It is preference because it is preferred to