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Define the Coenzyme activity of nicotinic acid?
Nicotinamide exists within the redox-active coenzymes, nicotinamide adenine dinucleotide (NAD) and its phosphate (NADP), which function in dehydrogenase-reductase systems requiring transfer of a hydride ion. NAD is also required for non-redox adenosine diphosphate-ribose transfer reactions involved in DNA repair and calcium mobilization. NAD functions in intracellular respiration and with enzymes involved in the oxidation of fuel substrates such as glyceraldehyde-3-phosphate, lactate, alcohol, 3-hydroxybutyrate and pyruvate. NADP functions in reductive biosynthesis such as fatty acid and steroid synthesis and in the oxidation of glucose-6-phosphate to ribose-5-phosphate in the pentose phosphate pathway. The role of NAD (P) is summarized in Table.
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