Define role of vitamin d in controlling gene expression, Biology

Assignment Help:

Define role of Vitamin D in controlling gene expression?

Vitamin D is a secosteroid that is metabolically activated and degraded through the actions of three cytochrome P450 hydroxylase enzymes. Bio activation occurs through the sequential actions of cytochromes (P450C25 and P450Cl) resulting in synthesis of the pleiotropic hormone 1,25-dihydroxyvitamin D (1,25VD), which regulates over 60 genes whose actions include those associated with calcium homeostasis and immune responses, as well as, cellular growth, differentiation and apoptosis, as you may recall studying earlier in Unit 7. Inactivation of 1,25VD occurs by C23/C24 oxidation pathways that are catalyzed by the multifunctional cytochrome P450C24 enzyme. Both P450C1 and P450C24 are highly regulated enzymes whose differential expression is controlled in response to numerous cellular modulatory agents such as parathyroid hormone (PTH), calcitonin, interferon gamma, calcium, phosphorus and pituitary hormones, as well as, the secosteroid hormone 1,25VD. 


Related Discussions:- Define role of vitamin d in controlling gene expression

Hazards of oxygen therapy - respiratory failure, Hazards of O 2 Therapy ...

Hazards of O 2 Therapy Exposure to greater than 60 per cent O 2 , for a period of more than 36 hours, or exposure to 100 per cent 0, for a period of more than 6 hours, res

Explain the term- latent squint, Explain the term- Latent Squint (Anisophor...

Explain the term- Latent Squint (Anisophoria or Heterophoria) This eye condition occurs when the balance of extra-ocular muscles is altered. There is a tendency of the eye to

Define causes of vitamin a deficiency - inadequate diet, Define Causes of V...

Define Causes of Vitamin A Deficiency - Inadequate diet? A child is born with poor stores of vitamins and minerals due to maternal malnutrition. Diets of pregnant women are def

Basic concepts of earthquake resistant structures, The aim of earthquake-re...

The aim of earthquake-resistant structure designing The main objectives of earthquake resistant structures are as follows: (i)     To avoid loss of lives due to the destruct

What is the function of the plant cell wall, Ans) The plant cell wall has s...

Ans) The plant cell wall has structural and protective functions. It plays significant role in the constraint of the cell size, preventing the cell to break when it absorbs much wa

Fine structure of pollen tubes grown in vitro, Fine Structure of Pollen Tub...

Fine Structure of Pollen Tubes Grown in Vitro The growth in pollen tubes is exclusively restricted to the tip. Cytochemical analysis reveals the pollen tip zone to be rich in

Which substances transferre from the mother to the fetus, Q. What are the m...

Q. What are the major substances transferred from the mother to the fetus through the placenta? And from the fetus to the mother? From the mother to the fetus the major transfe

What are the inheritance and dominance patterns of rh blood, What are the i...

What are the inheritance and dominance patterns of the Rh blood system? An inheritance pattern of the Rh blood system is autosomal dominant that is the heterozygous manifests a

Explain the functional properties of starches, Functional Properties of Sta...

Functional Properties of Starches Starch is a major source of energy (calories) in grains and tubers, and foods made from them. However, when starch is added to products as an

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd