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Modulation of the transcription of cell cycle proteins?
The 1,25-(OH),D compound (calcitriol), is present in the blood complexes to the vitamin D-binding protein, a specific a-globulin. Calcitriol is believed to act on target cells in a similar way to a steroid hormone. Free hormone crosses the plasma membrane and interacts with a specific nuclear receptor known as the vitamin D receptor, a DNA-binding, zinc-finger protein with a relative molecular mass of 55,000. This ligand-receptor complex binds to a specific vitamin D-responsive element and, with associated transcription factors (e.g. retinoid X receptor), enhances transcription of mRNAs which code for calcium-transporting proteins, bone matrix proteins, or cell cycle-regulating proteins.
Binding site is the place on cellular DNA to which a protein (like transcription factor) can bind. Typically, binding sites may be found in the vicinity of genes, and would be inv
In the case story, Reggie presented with three typical signs of hip fracture-shortening, adduction, and the lateral rotation of the affected limb. What causes these signs? (HINT-th
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assignment on tissues
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In-vitro studies Mechanistic data might be supplemented by data from in-vitro studies, like as information on genotoxicity derived from reversion assays or other same ass
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