Define mechanism for provide protection against colon cancer, Biology

Define Mechanisms for Provide protection against colon cancer?

Several plausable mechanisms have been formulated by which fibre may provide protection against colon cancer. These include:

1. Fibre that increases stool bulk results in the dilution of carcinogens. Fibre also decreases transit time thereby reducing the interactions of carcinogens with colonic mucosal cells.

2. Fibre binds potential carcinogens.

3. High bile acid concentrations are associated with increased risk of colon cancer. Fibres adsorb bile acids, thereby reducing the risk.

4. Fibre by providing fermentable substrate to colonic microflora alters species and number of microorganisms which may inhibit proliferation of tumor cells or conversion of procarcinogen to carcinogens.

5. Fermentation to SCFAs, reduces the pH, which in turn reduces synthesis of secondary bile acids. These bile acids have been shown to promote tumors.

6. Butyrate has been shown to have an effect on chromatin structure and thus could slow the proliferation and differentiation of cancer cells. Butyrate induces apoptosis (disintegration of cells).

7. Lignin may act as a free radical scavenger, thus reducing the risk of cancer.

Posted Date: 6/26/2013 2:36:16 AM | Location : United States

Related Discussions:- Define mechanism for provide protection against colon cancer, Assignment Help, Ask Question on Define mechanism for provide protection against colon cancer, Get Answer, Expert's Help, Define mechanism for provide protection against colon cancer Discussions

Write discussion on Define mechanism for provide protection against colon cancer
Your posts are moderated
Related Questions
Thermal Stratification - Lake Ecosystem Shallow lakes show no thermal stratification as their waters are well mixed, resulting in uniform temperature throughout. However lakes

Determine the case when starches treated with heat In the case of starches treated with heat in presence of acid or alkali, the alteration is a minor fragmentation; similarly,

Denaturing Gel is an agarose or the acrylamide gel run under conditions which destroy the secondary or tertiary protein or RNA. For protein, this generally means the inclusion of

different types of respiration

Determine Energy demand for Vigorous or vigorously active lifestyles? These people engage regularly in strenuous work or in strenuous leisure activities for several hours. Exam

Composition - Culture Medium A standard plant tissue culture medium (Basal medium) contains all the essential macro elements (Carbon, hydrogen, oxygen nitrogen, phosphorus, su

Ribavirin (Copegus, Rebetol, and others)  Combination treatment of HCV with peginterferon alfa and oral ribavirin has produced higher sustained response rates than peginterfero

Photosynthesis Two main energy pathways are recognised in living systems. These are photosynthesis and cellular respiration. Both have their respective but different electron

Describe PS With Atrial Right To Left shunt in details? This group of patients has cyanosis due to light to left shunt at atrial level. The diminution in PA pressure and PBF ma

Both global and regional systolic function are to be checked. Global measures include ejection fraction, stroke volume, end systolic volume. (For measurement of systolic function u