Define denaturation, Biology

Denaturation: With respect to the nucleic acids, refers to the conversion from the double-stranded to single-stranded state, many times achieved by heating or alkaline conditions. This is also known as "melting" DNA. In accordance to proteins, refers to the disruption of tertiary and the secondary structure, often attained by heat, detergents, chaotropes, and the sulfhydryl-reducing agents.

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