Define Carbohydrate Metabolism of manganese?

Mn is required for carbohydrate metabolism. Enzymes pyruvate carboxylase and phosphoenol pyruvate carboxy kinase involved in gluconeogenesis require Mn for optimal function. Further, animal studies strongly suggest a role for Mn in regulation of insulin transcription Ad I or in insulin mRNA turnover. Mn-deficient animals have been shown to exhibit a diabetic response to oral glucose challenges characterized primarily by impaired insulin production.