Deficiency diseases-thiamine deficiency (hypothiaminosis), Biology

Thiamine deficiency (hypothiaminosis)

Thiamine deficiency is characterized by signs of nervous system. The primary  thiamine deficiency is not common in animals. However, secondary deficiency has been reported in different species of farm animals.

Ruminants synthesize thiamine in rumen, whereas in monogastric animals, thiamine is microbially synthesized in alimentary tract. Primary thiamine deficiency of dietary origin  is  rare as most plants, especially the seeds and milk contain appreciable quantity of thiamine. An incidence of primary thiamine deficiency due to deprivation of feed during transport has been reported in literature.Secondary thiamine deficiency occurs due to destruction of the vitamin by the enzyme thiaminase. Cooking also destroys thiamine. Ingestion of excessive quantity of bracken fern and horsetail causes thiamine deficiency because of the high concentration of enzyme thiaminase. The coccidiostat amprolium is thiamine antagonist and its prolonged use can induce the deficiency of the vitamin.

Clinical findings: Bracken fern poisoning, a principal cause of secondary thiamine deficiency in horses, is clinically manifested by incoordination, falling and bradycardia. Horsetail poisoning is also characterized by similar signs. Initially there is swaying from side to side followed by pronounced incoordination, crossing of forelegs, arching of back, muscle tremors, and clonic convulsions followed by opisthotonous at the terminal stage. Hemiplagia of vocal cords is also found in horses.Experimentally induced hypothiaminosis in pigs was characterized by inappetance, emaciation, and leg weakness and falling. Lambs show signs of anorexia somnolence, and loss of condition followed by titanic convulsions.

Diagnosis: Signs of paralysis and reduced blood thiamine levels from normal range of 8-10 µg/dl to 2.5-3 µg/dl increased pyruvic acid concentration from normal values of 2-3 µg/dl to 6-8 µg/dl are indicative of thiamine deficiency in horses. Cases of encephalomyelitis caused due to other factors than thiamine deficiency fail to respond to thiamine treatment.

Treatment and Prevention:
Parenteral administration of thiamine @ 5 mg/kg body weight at 3 hourly intervals induces rapid therapeutic response. Daily oral doses of thiamine for 10 days, and correction of dietary abnormalities are effective therapeutic and preventive measures. Diet of monogastric animals should be supplemented with yeast, cereals and grains.

Posted Date: 9/19/2012 2:58:10 AM | Location : United States

Related Discussions:- Deficiency diseases-thiamine deficiency (hypothiaminosis), Assignment Help, Ask Question on Deficiency diseases-thiamine deficiency (hypothiaminosis), Get Answer, Expert's Help, Deficiency diseases-thiamine deficiency (hypothiaminosis) Discussions

Write discussion on Deficiency diseases-thiamine deficiency (hypothiaminosis)
Your posts are moderated
Related Questions
What is Pancreas ? The pancreas lies in the abdominal cavity in a loop between the stomach and small intestine. The pancreas consists of two major types of cells: those produci

How is the large size of some cephalopods related to the type of circulatory system they present? In cephalopods the circulatory system is closed and this gives more speed and

Define Reaction of Fehling solution with lactose? After complete reduction of cupric ions, the indicator is reduced by lactose to a leuco compound, restoring the red colour of

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

COMBINE D EFFECTS OF DRUGS AND ALCOHOL - 1.       Alcohol + Barbiturates →  may lead to death . 2.       Alcohol + Antihistamines → Drowsiness 3.       Alcohol + Valium

Operative requirements for stage i surgery Although Implant placement under general anesthesia must be done in an operating theatre with complete resources, most implant surger

Explain antimicrobial susceptibility All isolates of M. tuberculosis  should be tested for antimicrobial susceptibility. Initial therapy for most patients with active TB should

Simple diffusion Only comparatively small uncharged or hydrophobic molecules (H2O, O2, and CO2, other gases, urea and ethanol)   cross   the lipid   bilayer   through simple

Explain about the Dietary Calcium Requirements? There are variations in the amount of calcium recommended by different advisory groups. This is mainly due to the different crit