Claisen-schmidt reaction, Chemistry

Claisen-Schmidt Reaction:

In this exercise, you will make 2,2,6-trimethyl-5-phenylheptan-3-one by a reaction sequence which involves a Claisen-Schmidt  Reaction followed by the 1,4-addition of a Grignard reagent to a conjugated ketone:

Stage 1

C6H5-CH=O + CH3-CO-C(CH3)3  ---->     C6H5-CH=CH-CO-C(CH3)3 + H2O

Stage 2

(CH3)2CH-Br + Mg ---------->  (CH3)2CH-Mg-Br

C6H5-CH=CH-CO-C(CH3)3    ----------> C6H5-CH-CH2-CO-C(CH3)3

The reactions will give you experience of a number of techniques and concepts. These include

(a) use of extended reaction times;
(b) distillation under reduced pressure (‘vacuum distillation');
(c) working in a water-free system;
(d) differences in the IR absorption frequencies of conjugated and non-conjugated ketones;
(e) use of NMR in the determination of stereochemistry and structure


Safety : general

Carry out all work in a fume-cupboard, and observe normal good laboratory practice. Wear eye-protection, a buttoned-up lab-coat and gloves throughout this exercise. Treat all organic compounds as flammable, and do not bring them into direct contact with ignition sources. Ether is highly flammable: always work in a fume-hood and segregate totally from any work that uses naked flames.

Posted Date: 2/11/2013 6:25:19 AM | Location : United States







Related Discussions:- Claisen-schmidt reaction, Assignment Help, Ask Question on Claisen-schmidt reaction, Get Answer, Expert's Help, Claisen-schmidt reaction Discussions

Write discussion on Claisen-schmidt reaction
Your posts are moderated
Related Questions
Complex: A very general definition of complex is, 'A compound that results from the combination of a central atom or ion and a group of atoms/ions/molecules surrounding it'. As


When the azimuthal quantum number has a value of l=0 , the shape of the orbital is: (1) Rectangular (2)Spherical (3)Dumbbell (4)Unsymmetrical Ans: Spherical

what is meant by abnormal molecular mass of solute ? discuss the factors which bring abnormality in the experimentally determined molecular masses of solutes using colligative prop

Q. Uses of Aluminium? Aluminium exhibits useful properties of low density, high thermal and electrical conductivity, and good corrosion resistance with non-toxic nature of the

study the acidity of different sample tea leaves



calculate the ratio of the fundamental frequency of HI and DI

apparatus and principle of Flah photolysis...and 3rd order reaction with two same and one different concentration.