Antibody structure, Biology

Antibody Structure:

An antibody molecule consist of two alike light chains (220 amino acids each) ad two similar heavy chains (about 440-450 amino acids each) held together by disulfide bridges; this create the monomeric form of antibody. Enzymes papain cleaves particular monomeric form into two fragments that bind to the antigen (designated as FAB; fragment with antigen binding) and one fragment which does bid to antigen but make crystals (so it's called Fc, crystal forming fragment).

Approximate 100 amino acid long amino-terminal ends of both light and heavy chains add up to their variable region denoted VL and VH, correspondingly; the amino acid sequence of this regions of the heavy and light chains are known constant region (designated as CH and CL, correspondingly) as there is little variation in the amino acid sequence of this region between the antibodies belonging to the same class.

Every antibody molecule has two antigen-binding domains or sites, particular domain being constituted by the variable regions of one light and one heavy chains of an antibody molecule form its effectors function domain that determines its interaction with the other components of the immune system. The light chains are of two types: and lambda (λ) and Kappa (K) ; the type of a light chain is find out by its constant region.

Different genes encode the Kappa (located in human chromosome 2) and lambda (chromosome 22) light chains, and the heavy chain (chromosome 14).

The variable region of particular chain contains 3 highly variable regions known hyper variable regions and denoted as CDR1CDR2and CDR3 (CDR = complementarily-determining region) divided by 4 constant regions known framework regions (this is designated as FR1, FR2FR3FR4). The constant region of particular heavy chain has 3 homologous regions (CH1CH2 and CH3) which most likely originated from a common parental gene (3 tandem repeats of the parental gene, by following mutations).

Posted Date: 10/2/2012 1:20:19 AM | Location : United States

Related Discussions:- Antibody structure, Assignment Help, Ask Question on Antibody structure, Get Answer, Expert's Help, Antibody structure Discussions

Write discussion on Antibody structure
Your posts are moderated
Related Questions
Overgrazing - Degradation of Ecosystem It refers to the condition when the grazing pressure on the vegetation is so intense that it does not recover. Ultimately, there is a lo

Why should Posterior wall preffered during surgery Posterior wall should not be perforated during surgery. This limits bleeding from the pterygoid plexus or branches of the max

How to calculate protein percentage in Lowry method? Ans) By verification of optical density by coloimetric method

Which kind of weak interaction can define higher order structure and in the same time DNA.

TELEMENTORING Telementoring is used by a nursing teacher providing training/advice? to another nurse consultant at a remote site. The Internet has made teleconsultation and t

Interactions between Volatile Substances and Proteins               Flavour binding may involve adsorption at the surface of food or penetration to the food interiority by diffu

Procedure for Test the Presence of Sugar in Honey? 1. Mix 5 grams of honey with 5 ml ether in a mortar and pestle. 2. Decant off the ether extract into an evaporating dish.

How is the nervous system of molluscs organized? Molluscs have well-developed sensory structures. It is established that cephalopods, such as squid and octopus, have eyes with

Q. Can Serotonin used in consciousness? Serotonin complements the action of noradrenalin and acetylcholine in promoting wakefulness and cortical responsiveness. Experiments pro

what are the methods of seed formation