Animal disease model, Biology

Animal disease model

The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.

Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.

Posted Date: 9/18/2012 7:56:42 AM | Location : United States







Related Discussions:- Animal disease model, Assignment Help, Ask Question on Animal disease model, Get Answer, Expert's Help, Animal disease model Discussions

Write discussion on Animal disease model
Your posts are moderated
Related Questions
Define Importance of nutritional requirements for management of emergencies? Knowledge of nutritional requirements for management of emergencies is therefore, important due to

Retrograde Peri-Implantitis It has been described by Misch as implant failure probably due to bone microfractures caused by premature implant loading or overloading, other form

Types of cells in Phloem The phloem consists of 4 types of cells: i).sieve elements, ii) companion cells, iii) phloem parenchyma and sometimes iv) phloem fibres. The metabolit

Which type Ribosome occurs exclusivley in Mitocondria?

Freediving is an activity in which a person dives, sometimes to great depth, without the use of scuba gear. The diver must hold his or her breath for the duration of the dive. (The

Explain about Osteogenesis Osteogenesis, large amounts of woven bone can be formed very rapidly. This bone is believed to be much more compliant than organized lamellar bone. I

Fusion inhibitor  After HIV binds to the host cell surface, a conformational change occurs in the transmembrane glycoprotein sub- unit (gp41) of the viral envelope, facilitatin

How many different types of gametes can be formed by individuals of the following genotypes? What are they in each case a) AaBb b) AaBB c) AaBbCc d) AaBBCc e) AaBbcc f) AaBbCcDdEe

A dihybrid cross yields 320 F2 offspring. How many are expected to resemble the homozygous recessive parental?

Oogenesis  The process of formation of ova in the ovary is called as oogenesis. The germ cells are found in the form of germinal epthelium around the ovary.These cells are d