What is basis for affinity maturation in humoral responses

Assignment Help Biology
Reference no: EM13939593

As humoral responses progress, the average affinity of the antibodies produced rises, in a process known as "affinity maturation." This seems at odds with at least one aspect of the clonal selection hypothesis, since the notion of "clonal integrity" implies that the progeny of an activated lymphocyte retain the specificity the original, pre-immune, antigen receptor. So here are the questions:

What is the basis for "affinity maturation" in humoral responses?

Does this contradict the tenets of clonal selection? Perhaps a bit more broadly, does this force rejection of the clonal selection hypothesis as a viable model to explain the cellular basis for specificity of adaptive immunity?

At the end of the response, you should raise an issue you are curious about related to the topic in the question.

Reference no: EM13939593

Questions Cloud

Compute the levered bheta : We have the X firm on which we have the following information. Its bheta unlevered is 3, its D/E is 4/1, and its tax rate is .3. Additionally we know that the default free rate is 5% and the stock market has returned 11 % over a long period of time. ..
Problem regarding the state leaders-politicians : You are required to select one of the famous (current or past) state leaders/politicians from the List A and one of the famous (current or past) CEOs from the List B.
Business report on application of cultural approaches : Description/Focus: Business Report on application of cultural and critical approaches to an Australian Organization.
Calculate after-tax cash flow at disposal : Genetic Insights Co. purchases an asset for $11,576. This asset qualifies as a seven-year recovery asset under MACRS. The seven-year fixed depreciation percentages for years 1, 2, 3, 4, 5, and 6 are 14.29%, 24.49%, 17.49%, 12.49%, 8.93%, and 8.93%, r..
What is basis for affinity maturation in humoral responses : Does this contradict the tenets of clonal selection? Perhaps a bit more broadly, does this force rejection of the clonal selection hypothesis as a viable model to explain the cellular basis for specificity of adaptive immunity?
What is the effective annual yield-current yield on the bond : Martin Software has 8.2 percent coupon bonds on the market with 21 years to maturity. The bonds make semiannual payments and currently sell for 106.9 percent of par. What is the current yield on the bonds? What is the effective annual yield?
Attempted to increase its business by marketing : A mortgage lender attempted to increase its business by marketing its subprime mortgage. This mortgage is designed for people with a less-than-perfect credit rating, and the interest rate is higher to offset the extra risk. In the past year, 20% o..
Write a driver program to test your function : Also write a driver program to test your function. What happens if you enter units other than those listed?
Bonds for some much-needed expansion projects : Coccia Co. wants to issue new 18-year bonds for some much-needed expansion projects. The company currently has 9 percent coupon bonds on the market that sell for $1,045, make semiannual payments, and mature in 18 years.

Reviews

Write a Review

 

Biology Questions & Answers

  Develop a health campaign to implement change in population

Develop a health campaign to implement a change in population health. Focuses on recommendations for implementing and assessing the proposed change

  The most likely diagnosis on the differential is

Discuss how medical technologies are evaluated. Give examples of at least two evaluation methods that have been discussed either in popular press or scholarly journals.

  Assume complete dominance and independent assortment

Given the parents AABbCc × AabbCc, assume complete dominance and independent assortment. What proportion of the progeny will be expected to phenotypically resemble the first parent?

  Outline a nutritional treatment strategy

Give a brief description, discuss the cause and pathogenesis (with emphasis on the nutritional understanding of these), outline a nutritional treatment strategy, and design a dietary programme specifically beneficial to the condition.

  Cellular respiration occurs in both plants and animals cells

Cellular respiration occurs in both plants and animals cells while photosynthesis only occurs in plant cells.  How are plants and animals connected via these two processes?  Be sure to include balanced chemical equations as part of your answer.

  Catabolism is convergent and anabolism is divergent

What does it mean that catabolism is convergent, and anabolism is divergent? Usespecific examples. Given that slow-twitch muscletends to be used in aerobic efforts, while fast-twitch muscle tendsto be used in sprints, which would you expect to stor..

  What does the refuse tell you about the household

The things left behind or thrown away can hold more information about the people doing the discarding then their cities and monuments. What does the refuse tell you about the household

  Question about genetic drift

Populations evolve for many reasons. Assume there is a population of plants that have either purple flowers or white flowers, and allele for purple flowers is dominant.

  The title of your presentation is water the overlooked

the title of your presentation is water an overlooked essential nutrient. a law firm has requested that you introduce

  What effect does the indicated mutation of c to a have

What effect does the indicated mutation of C to A have in this sequence?

  Means chemically for a protein to be denatured

Define what it means chemically for a protein to be denatured

  Write an indigenous health issue

Write an Indigenous health issue, the impact that this health issue has on Indigenous peoples and identify programs for achieving better health outcomes

Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd