What combination therapies can be beneficial
Course:- Biology
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1. Present the comparison of clinical benefit of the use of drugs for Parkinson's Disease. What combination therapies can be beneficial?

2. Present the most current strategies for the treatment of Alzheimer's Disease.

3. Compare the benefits and side effects of tricyclic antidepressants, SSRIs, SNRIs and atypical antidepressants.

4. Present the rationale for clinical applications of inhalational and intravenous anesthetics. What are major factors affecting the induction of anesthesia? What are side effects of the use of inhalational and intravenous anesthetics?


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The progressive disorder, Parkinson's syndrome is related to nervous system, characterized by the tremor; a slow and delayed in movement (often, referred as bradykinesia); the muscle rigidity and stiffness; and instabilities in posture (i.e., imbalance during walking or standing). The disease occurs as a result of deterioration of nerve cells in substantia nigra of the brain.

It further leads to an impairment of in the secretion of the chemical messenger, dopamine. The chemical messenger acts as a communication module between the substantia nigra and corpus striatum, resulting in maintaining a coordination of balanced muscle movements (Schapira, 2006). Due to abnormalities in nerve cells, and production of dopamine, impact control and thus body movements.

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