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Q. After prolonged exposure to isoproterenol, that binds to b-adrenergic receptors and activates adenylate cyclase, cells become refractory and cease responding. To investigate this phenomenon, you treat cells for a variety of times with isoproterenol, wash it out, and next assay for b-adrenergic receptors by measuring binding of dihydroalprenolol, that is hydrophobic, and CGP-12177, which is hydrophilic. You find that CGP-12177 binding decreases in parallel to adenylate cyclase activity while dihydroalprenolol binding remains high. When you lyse isoproterenol-treated (desensitized) cells and fractionate membrane-enclosed vesicles by centrifugation through sucrose-density gradients, you find out that CGP-12177 binds only to vesicles derived from the plasma membrane (as indicated by the presence of the marker enzyme, 5'nucleotidase) whereas dihydroalprenolol binds to an extra population of vesicles as well.
a. Give an description for the differences in binding between CGP-12177 and dihydroalprenolol;
b. What do you think may be the basis for isoproterenol-induced desensitization in these cells?
Comprise in the discussion cellular and fluid composition of blood. We have headaches daily, itch constantly what is really weird is all our hair turned in to this wirey frizzy uncontrollable mess and we have all this like hair or fiber substance com..
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While the nurse applies the sharp point of the pin on his arm several times, he is only able to identify these as one "very sharp prick." What would be the most correct explanation for this.
The bacteria are allowed to grow overnight and are streaked on a plate using the technique that produces isolated colonies that are clones of the original. Samples of these colonies are then grown in four different media: nutrient broth plus ampicill..
Madagascar, Indonesia and the Amazon basin have some of the greatest numbers of different species concentrated in a single area. What kinds of environments do you think encourage greater biodiversity.
If a transferrin receptor has a cross-sectional area of 50 Angstroms X 100 angstroms (5x10nm), and how many receptors could be accomodated in a 100nm clathrin-coated vesicle assume that only 50% of surface area can be occupied by proteins.
Understand the section on spermatogenesis. Do you think the age of the man is as important in determining the chance of chromosomal abnormalities? Why or why not give reasons.
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