Southern blot to detect the junction fragment

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Reference no: EM1386559

Diagnosis of CML can be done using a Southern blot to detect the junction fragment. In the early stages of CML most patients are heterozygous for the genome rearrangement, while at later stages homozygosity is observed. Using a probe that detects both the junction fragment and the normal cABL gene, would you be able to distinguish between someone that is heterozygous and someone that is homozygous?

yes
no

 

Reference no: EM1386559

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