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Imagine that a pharmaceutical company, specifically the research and development division, just hired you. Your first assignment consists of developing a new anticancer drug to control the high rates of glycolysis in tumor cells. Your company wants to target an enzyme different to hexokinase II, because they want to get ahead of competition (hexokinase inhibitors are popular drugs). What glycolytic enzyme (s) would target? Why? If you are not successful targeting glycolytic enzymes, how would you attempt to inhibit glycolysis? Provide at least one example to support your answer.
Distribute one cup with sugar water and one with fresh water. Take a sip of the sugar water and swish it around in your mouth for several seconds without swallowing it; gradually, it has to tasteless sweet. After swallowing it (or spitting it back in..
You solve the structure of a non-specific RNA binding protein and find a pocket of K and R amino acids. Explain a possible mechanism for the protein-RNA interaction.
Diploid nuclei of the ascomycete, Neurospora crassa, contain 14 chromosomes. A single diploid cell in an ascus will undergo one round of meiosis, followed in each of daughter cells by one round of mitosis, producing a total of eight ascospores.
How many pairs of genes regulating tail length character. Adding of H+ or OH- to a reaction increased its overall rate indicating the rate limiting step was the addition of H+ or OH- to the intermediate. Is this really true? Why or why not.
Determine which of the following groups can be involved in hydrophobic interactions?
Which food item would cook the fastest and why with reason. What are the similarities between G-protein receptor systems and Tyrosine-kinase receptor systems.
Which minerals make up the majority of bone tissue, and what is their general structural purpose?
What are the roles of acrorhagi, acontia, and catch tentacles in mediating the competition for space among sea anemones and corals?
Find the number alive and the number dying in a discrete reproduction life table for a hypothetical cohort of 1000 individuals.
Assume you construct a screening method for cystic fibrosis that allows you to identify the predominant mutation?508 and the next six most prevalent mutations.
A seven cm potato sliced is placed into an unknown solution. After the slice is immersed for one hour, the potato slice now measures six cm.
Inversion or Translocation heterozygotes have difficultyin producing gametes that function properly. Is there a way that an Inversion heterozygote could manufacture functional gametes?
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