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The uniform arrangement of the backbone carbonyl oxygens and amide nitrogens in an α helix gives the helix a net dipole, so that it carries a partial positive charge at the amino end and a partial negative charge at the carboxyl end. Where would you expect the ends of α helices to be located in α protein? Why?
Comparison of a homeodomain protein from yeast and Drosophila shows that only 17 of 60 amino acids are identical. How is it possible for a protein to change over 70% of its amino acids and still fold in the same way? Can you mention one example?
In 1968 Cyrus Levinthal pointed out a complication in protein folding that is widely known as the Levinthal paradox. He argued that because there are astronomical numbers of conformations open to a protein in the denatured state, it would take a very long time for a protein to search through all the possibilities to find the correct one, even if it tested each possible conformation exceedingly rapidly. Yet denatured proteins typically take less than a second to fold inside the cell or in the test tube. How do you suppose that proteins manage to fold so quickly?
The two main reasons for the resurgence in TB are HIV and drug-resistant strains of the organism. Why is this so
How does cAMP work?
Arthropods are the most diverse group of animals. Describe some characteristics of arthropods that may have contributed to their great evolutionary success.
q. your friend is studying mouse fur color and has isolated the gpcr responsible for determining its color as well as
What are three categories of genes that when mutated can lead to tumor formation? Describe the characteristics of each category.
What is the main cell organelle involved in cell digestion? What properties of that organelle allow it to carry out its task?
Describe inflammation using at least three leukocytes to descibe the process.
How do codons relate to primary structure of proteins? Be able to construct a strand of messenger RNA from the sense strand of DNA (TRANSCRIPTION) and understand where this happens in a cell. How does the RNA differ from the DNA? How do mutations in ..
An athlete travels to the Colorado Rockies to train for an upcoming marathon. He runs 15 miles every other day and while breathing O2 deficient air. His blood O2 levels become lowered as a result. His kidney cells sense the reduction in O2 and sec..
The next litter produced 8 white, mule-footed offspring and one white clove-footed pig. Now, what is the most probable genotype of the sow.
compare and contrast the three types of species (rank) abundance curves. An explanation of what each one represents in terms of niche relationships among the species in a community is needed. Thanks
What is a "Holliday Structure"? Describe the differentially resolved heteroduplexes and recombinants.
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