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Trypanosoma brucei is the agent that causes African sleeping sickness in humans bitten by the tsetse fly. Glycolysis is unusual in this organism, providing an opportunity to create drugs that poison the parasite without harming humans. In T. brucei, the seven glycolytic enzymes converting glucose to 3-phosphoglycerate are localized in specialized peroxisome-like organelles called glycosome. One molecule of each glycerol and pyruvate are produced per molecule of glucose. The net ATP production is one molecule. Based on this information, compare and contrast the glycolysis pathways in T. brucei and other organisms (like human), and explain how the glycerol is produced and why only one net molecule of ATP is produced. What enzyme(s) do you think we can target to kill trypanosomes with minimum side effects on human. Rationalize your target(s). (Hint: How is glycerol produced and why only one ATP is generated in T. brucei).
The symptom of numbness of the palmar region often associated with carpal tunnel syndrome is caused by: Compression of the long extensor muscles of the hand. Compartmentalization of flexor and extensor muscles.
Members of the genus Mycoplasma stain Gram negative although the taxonomically grouped with Gram positive bacteria. The organism Deincoccous radiodurans grouped with the Gram negative alpha-Proteobacteria, yet it typically stains Gram positive.
q1. explain how humans have impacted the biome in which you live. list the types of environmental damage that have been
When using the Nernst equation to calculate membrane potential, we are making several assumptions about conditions in the cell. Which of the following is not a good assumption?
The gibbon has 44 chromosomes per diploid set; the siamang has 50 chromosomes per diploid set. In the 1970s a chance mating between a male gibbon and a female siamang produced an offspring.
Which of the following statements about immature naïve B cells that have been released from the bone marrow is not true?
Determine which type of chromosome structure is characterized by the centromere position very near the end of the chromosome with the short arm composed of highly repetitive DNA?
A particular Drosophila female that is wild-type in appearance is known to be heterozygous for the three recessive mutations black body (b), curved wings (c) and purple eyes (p).
Local government leaders have asked you to provide information and recommendations for increasing sustainability in the community. Perform an initial search to learn about green initiatives for a city in your area.
Since it takes 40 min. to replicate the E. coli chromosome, how can the cell have a cell cycle of 35 minutes?
Polio and HIV are both +ssRNA viruses have very different strategies for replicating their genomes. After the viral genomes enter the cell, explain the first step involved in replication of each genome.
What would happen to a signaling pathway if a mutation in phosphodiesterase rendered it nonfunctional?
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