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Given the following data, assess whether human hematopoietic stem cells can truly self-renew in vivo. & About 400 billion mature hematopoietic cells are produced daily.
The best estimate of the Hayflick limit is 44 to 50.
About 1:5000 progenitors do NOT apoptose.
About 50 to 1000 mature cells are made per progenitor (6 to 10 doublings).
The entire differentiation pathway may be 17 to 20 doublings (soft fact).
About 10 to 30 million cells at most can be made from a highly purified single hematopoietic stem/preprogenitor cell in vitro.
Present order of magnitude calculations in constructing your decision. Also perform parameter sensitivity analysis of each of the parameters that govern the hematopoietic process. How important are the parameters that govern telemorase activity in determining the total number of mature progeny produced over a person's lifetime?
Adsorption and Membrane Processes
A recovery of 95% of particles greater than 100 μm is required. The minimum operating temperature will be 10 °C and the maximum 30 °C. Design a hydro cyclone system to handle 1200 liters/min of this slurry.
Obtain an expression for the induced emf, assuming the angle θm is zero at t = 0 and θm = ωmt.
Compute the theoretical density of diamond given that the C-C distance and bond angle are 0.154 nm and 109.5°, respectively. How does this value compare with the measured density?
Draw the cycles on P-h and T-s diagrams
question 1a describe the main purpose of the globally harmonised system of classification and labelling of chemicalsb
1. find laplace transforms of the following functions where a b and c are constants.a. a bt ct2b. asin2tc.nbsp e-3t2.
A liquid mixture consisting of 100 kmol of 60 mol% benzene, 25 mol% toluene, and 15 mol% o-xylene is flashed at 1 atm and 100°C. (a) Compute the amounts of liquid and vapor products and their composition.
1discuss an incident fire spill explosion etc that you have experienced or research one on the internet professional
Calculate the resistance of the armature circuit and the field circuit.
Estimate the heat-transfer coefficient for steam condensing on the outside, and on the inside, of a 25 mm o.d., 21 mm i.d. vertical tube 3.66 m long. The steam condensate rate is 0.015 kg/s per tube and condensation takes place at 3 bar
A 50-kW, 250-V, short-shunt compound generator has the following data: Ra = 0.06 Ω, RS = 0.04 Ω, and Rf = 125 Ω. Calculate the induced armature voltage at rated load and terminal voltage. Take 2 V as the total brush-contact drop.
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