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Cocaine overdose and addiction are major public health problems. One novel treatment involves the administration of high activity mutants of human butyrylcholinesterase (BChE) (i.e. this would be a protein-based ‘drug') that would hydrolyze and detoxify cocaine.
Explain how His438 and Glu325 act together to generate a better nucleophile at Ser198.
The Ser198Ala, His438Ala, Glu325Ala triple mutant still catalyzes the ester hydrolysis of cocaine by a ~1000-fold over the uncatalyzed reaction.
Explain how the triple mutant enzyme can still catalyze the reaction when the catalytic triad has been ‘knocked out.'
One mutation that increases the catalytic activity of BChe is the Ala199 to Ser mutation. The hydroxyl group of Ser199 makes a hydrogen bond interaction with the carbonyl oxygen in the cocaine ester. Explain how an extra hydrogen bond to this carbonyl oxygen may increase the enzyme's catalytic rate.
Calculate the pH at the equivalence point in titrating 0.120 M solutions of each of the following with 8.0* 10^-2 M NaOH
"Discuss in detail, one way in which atomic nuclear decay takes place. What is the significance of atomic nuclear decay? Analyze the societal implications of using this process".
The equilibrium constant is 100. Calculate the concentrations of O2 present at equilibrium
A sample of ethanol (C2H5OH) has a mass of 43.8 g.(a) How many carbon atoms does the sample contain?
Determine how many grams of C 6 H 12 O 6 should be mixed in 563 grams of C 2 H 5 OH) to form a 2.40X10^-2 m solution?
How can their efficiency be less than 100% and the Law of Conservation of Energy still be valid? An incandescent light bulb functions because of the flow of electric current. Does the incandescent light bulb convert all of the electrical energy to..
What mass of this substance must evaporate to freeze 185g of water initially at 17 degrees Celsius? (The heat of fusion of water is 334J/g; the specific heat of water is 4.18 J/g-K.)
The enthalpy change at 25C and 1 atm for the complete burning of 1 mol of acetone in oxygen to give CO2(g) and H2O(l) is -1791kJ. Calculate the standard enthalpy of formation of acetone.
What is the major role of a greenhouse gas that contributes to temperature rise of the Earth's surface? 1 Stops both incoming sunlight and outgoing infrared radiation
If 5.36 103 kg each of NH3, O2, and CH4 are reacted, what mass of HCN and of H2O will be produced, assuming 100% yield?
Benzoic acid can be extracted from an ether solution using an aqueous solution of sodium bicarbonate.
When you heat baking soda (NaHCO3), it breaks down into sodium carbonate powder (Na2CO3), carbon dioxide and water vapor. Write a correct thermo chemical equation and explain what it tells you about the reaction ( The enthalpy of this reaction is ..
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