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Question: A diffusion cell is constructed that consists of a thin membrane (thickness 200 micro meters and area 1 cm^2) separating two solutions of identical volume (V= 10 cm^3). The donor solution contains a drug molecule of interest. The drug has a partition coefficient of 15 in the membrane. State all your assumptions and boundary conditions in the calculation.1) If the donor solution concentration remains unchanged at 10 mg/ml. The receptor solution is maintained at a much lower concentration. The amount of drug that passes through the membrane is 6.5 mg/hr. Calculate the drug diffusion coefficient and permeability in the membrane.(2) If the initial drug concentrations are 10 mg/ml in the donor solution and 0 mg/ml in the receptor solution. The change in the drug concentration in the receptor solution is measured as a function of time, as shown in the table below. Also shown is the drug concentration change when the membrane is treated with a thin layer of coating. Determine the permeability of the membrane with and without coating to the drug.Time (min) Without coating (mg/ml) With coating (mg/ml)0 0 060 0.45 0.1300 1.35 0.5900 2.5 1.3
Destroying the Trojan horse. Penicillin is hydrolyzed and thereby rendered inactive by penicillinase, an enzyme present in some resistant bacteria.
Suppose if insulin were treated with mercaptoethanol to break its disulfide bonds, and then the mecaptoethanol were removed so that disulfide bonds could reform,
No structures needed but show all the substrates involved in each reaction and the name of the enzyme. Changed mechanism of the transmission of infectious bacterial diseases with examples.
The phylum porifera consists of sponges which are essentially colonies of flagellated cells. Which of the following is a characteristic of the phylum
Question: The genomes of (+) RNA viruses can be translated immediately upon cellular entry, even though they do not possess a 5' 7-methylguanosine cap due to the presence of this structure at the 5' end of the genome [x]
An organism of the genotype AaBbCc was testcrossed to triply recessive organism. The genotypes of the progeny are presented in the following table.
Describethe results, in the context of the rate of electron flow through the thylakoid membrane, and is the light saturation effect taking place, based on my results.
Create Lotka-Volterr model equation that describes population of prey and predators and define each term in your equation.
I am conducting an activity assay to assess the Enzymatic Hydrolysis of 4-Nitrophenyl ?-D-Glucopyranoside by ?-D-Glucosidase. I am happy with the assay, though one of the components is bovine serum albumin ( 0.2% solution in phosphate buffer, to w..
Is habitat temperature reflected in the genomes? What is presumably connected to thermostability.
Insulin is a secreted protein made by islet cells in the pancreas. The gene INS encodes the precursor for insulin protein. Explain the flow of data from the INS gene.
A patient suffers with symptoms of an upper respiratory infection, especially nasal congestion. Determine which category of autonomic drugs would be the best choice for his treatment?
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