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Describe the journey of a hypothetical enveloped (-) RNA virus through three basic host barriers to infection: Physical b arriers, Innate immune response and adaptive immune response. After overcoming physical barriers, how are viruses recognized at each step, what cells are involved, what soluble factors are involved, which adaptive immune effector cells recognize F and N viral proteins and how is the virus eliminated at each step? For simplicity, let's assume the only the Fusion Protein (F) and Nucleoprotein (N) are recognized by the adaptive immune response (500 words max).Part BAlmost all viruses have to produce viral proteins that aid evasion of the host immune response. For each of the viral proteins listed below, explain why the activity described would enable the virus to avoid immune response. What aspect of the immune response does the protein inhibit (intrinisic, innate or adaptive) Limit response to 4-5 sentence/protein.a) In addition, to facilitating transcription of viral genes, the P protein also inhibits the TAP1 transporter located in the membrane of the ER membrane.b) In addition to coating the viral RNA, the N protein inhibits the host enzyme PKR.c) Matrix protein M bines to the host myd88 protein and inhibits its ability to transduce signals in the cell.
A researcher has come up with 5 hypotheses - based on what you know about the key milestones of life which do you think is most likely to be true?
How can you find the actual duration from the relative duration? Say the relative duration was 44% and you had to find the actual duration in minutes.
The muscles that originate on the ischium and sacrum are" Adductors of the thigh. Abductors of the thigh. Medial rotators of the thigh.
What is ATP and What is its role in the functioning of cells? What is free energy and what does the change in free energy tell one about a chemical reaction? Chemical structure of Glucose and How many Carbon-Carbon and Carbon-Hydrogen bonds are th..
Smurfs are imaginary creatures who are normally blue (B), fuzzy (F), and industrious (I). Data from a testcross are shown below.
A microelectrode provides a current pulse that depolarizes the axon-just above threshold. Describe the events that occur immediately after reaching threshold.
An important group of peripheral membrane proteins are enzymes such as the phospholipases that cleave the head groups of phospholipids. What properties must these enzymes exhibit?
You do DNA analysis of a newly found species of mammal and find there to be 7 JK and 65 VK sequences. Assuming that any V sequence can join any J sequence.
Arrange the amino acid substitutions in increasing order of conservatism and amino acids are given using one letter codes to give you some practice in using those.
Why is methanol used in the process of destining proteins in a SDS-PAGE gel?
How could you explain the occurrence of birth defects (caused by altered genes) in children and grandchildren of WWII atomic bomb victims, while the victims themselves were only mildly affected.
A protein has an apparent mass of 800 kD by gel filtration chromatography, but SDS-PAGE shows a single band at a position corresponding to 200 kD. In an ultracentrifuge, will the protein exhibit a sedimentation coefficient corresponding to 200 kD ..
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