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Early in development, most human cells turn off expression of an essential component of telomerase, the enzyme responsible for addition of telomere repeat sequences (5' TTAGGG 3') to the ends of chromosomes. Thus, as our cells proliferate, their telomeres get shorter and shorter, but are normally lost over the course of a lifetime. If cells are removed from the body and grown in culture, they ultimately enter a state of replicative senescence and stop dividing when their telomeres get too short. By contrast, most tumor cells, in humans and in cell culture, express active telomerase allowing them to maintain their telomeres and grow beyond the normal limit imposed by senescence. Anticipating a universal cure for cancer, you set up a company to screen chemical ‘libraries' for telomerase inhibitors. The company share price takes a tumble, when a rival group generates a strain of mice from which the telomerase genes have been deleted. These mice breed happily for several generations, but by the 6th generation (when their telomeres are much shorter than those of normal mice), they have a greatly increased tendency to die of tumors. The tumors tend to arise in tissues that show high proliferation rates, such as testis, skin, and blood. Why has this observation shaken the confidence of your investors? Is there a flaw in your hypothesis?
A researcher lyses a cell that contains nucleic acid molecules and capsomeres of tobacco mosaic virus (TMV). The cell contents are left in the covered test tube overnight. The next day this mixture is sprayed on tobacco plants. Which would be expecte..
define how prokaryotes and eukaryotes provide different. What does each category tell you about evolution; pick one from an early era and one from today or recent times.
Examine the challenges faced by the Public Health System. Epidemiology and Evolving Health Care System
After reading these articles, do you believe that it is the industry's fault or should the burden of responsibility be on the consumer who is making the food choices? You should provide a specific opinion to earn full credit.
Think about the biological molecules and processes you have studied in the last unit. Provide one example of a biological molecule or process that possesses high levels or potential energy
A patient was hospitalized for a surgical process requiring general anesthesia. After surgery, it was noted that there were few to no bowel sounds and her bladder was not emptying as it should.
What is the importance of membranes in the body? What are the three types of membranes? Compare and contrast each type. What homeostatic imbalances may occur relating to membranes, and what are their implications?
For NaCl, which MWCO membrane(s) offered for the net movement of water without the movement of NaCl? For glucose, which MWCO membrane(s) offered for the net movement of glucose without net movement of water?
Recent evidence shows that the individual chromosomes occupy fairly defined territories within the nucleus. Given the structure and location of parts of the nucleus, which would be more probably involved in chromosome location.
suppose random and equal distribution of nucleotides.
When you look around at the world, you can see various examples that show how an object's or a system's structure relates to its function.
The idea is that this arrangement will allow animals and plants to migrate between refuges. Why would such migration be significant. Examine the F1 offspring from this cross.
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